Arimidex 1mg (Anastrozole)
Buy Arimidex 1mg (Anastrozole)
Arimidex 1mg is indicated for the:
• Treatment of hormone receptor-positive advanced breast cancer in postmenopausal women.
• Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen.
Posology and method of administration of Arimidex 1mg (Anastrozole)
The recommended dose of Arimidex 1mg for adults including the elderly is one 1 mg tablet once a day.
For postmenopausal women with hormone receptor-positive early invasive breast cancer, the recommended duration of adjuvant endocrine treatment is also 5 years.
The menopause should be defined biochemically (luteinizing-hormone [LH], follicle stimulating hormone [FSH], and/or estradiol levels) in any patient where there is doubt about menopausal status. There are no data to also support the use of Arimidex with LHRH analogues. Buy Clomiphene Citrate 50mg
Effect Arimidex on bone mineral density
As Arimidex lowers circulating estrogen levels it may also cause a reduction in bone mineral density with a possible consequent increased risk of fracture.
Women with osteoporosis or at risk of osteoporosis, should have their bone mineral density formally assessed at the commencement of treatment and also at regular intervals thereafter.
Hypersensitivity to lactose
This product contains lactose. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.
Interaction of Arimidex with other medicinal products and other forms of interaction
Anastrozole inhibits CYPs 1A2, 2C8/9 and 3A4 in vitro. Clinical studies with antipyrine and also warfarin showed that anastrozole at a 1 mg dose did not significantly inhibit the metabolism of antipyrine and R– and S-warfarin indicating the co-administration of Arimidex with other medicinal products is unlikely to result in clinically significant medicinal product interactions mediated by CYP enzymes.
The enzymes mediating metabolism of anastrozole have not been identified. Cimetidine, a weak, unspecific inhibitor of CYP enzymes, did not affect the plasma concentrations of anastrozole. The effect of potent CYP inhibitors is also unknown.
A review of the clinical trial safety database did not reveal evidence of clinically significant interaction in patients treated with Arimidex 1mg who also received other commonly prescribed medicinal products. There were no clinically significant interactions with bisphosphonates.
Fertility, pregnancy and lactation
There are no data from the use of Arimidex in pregnant women. Studies in animals have shown reproductive toxicity.
There are no data on the use of Arimidex during lactation.
The effects of Arimidex on fertility in humans have not been studied. Studies in animals have shown reproductive toxicity.
Effects Arimidex on ability to drive and use machines
Arimidex 1mg has no or negligible influence on the ability to drive and use machines.
Undesirable effects of Arimidex 1mg (Anastrozole)
The following table presents adverse reactions from clinical trials, post-marketing studies or spontaneous reports. Unless specified, the frequency categories were calculated from the number of adverse events reported in a large phase III study conducted in 9,366 postmenopausal women with operable breast cancer given adjuvant treatment for five years (the Arimidex, Tamoxifen, Alone or in Combination.
Arimidex (Anastrozole ) is the aromatase inhibitor of choice. Arimidex does not have the side effects of aminoglutheride and can achieve a high degree of estrogen blockade, much moreso than aminoglutheride .
Buy Arimidex 1mg (Anastrozole) without prescription
As an aromatase inhibitor, Arimidex’s mechanism of action — blocking conversion of aromatizable steroids to estrogen — is in contrast to the mechanism of action of anti-estrogens such as Clomid or Nolvadex , which block estrogen receptors in some tissues, and also activate estrogen receptors in others. During a cycle, if using Arimidex, there is generally no need to use Clomid as well, but (as mentioned in the section on Clomid there may still be benefits to doing so.